Everolimus in the management of metastatic neuroendocrine tumours
نویسندگان
چکیده
منابع مشابه
Appendicular Neuroendocrine Tumours in Children: Unicentric Retrospective Study
Background: Neuroendocrine Neoplasms (NEN) represent 60% of all appendicular tumours. This type of cancer is predominantly benign. In this study, appendicular NEN tumours in children were investigated. Materials and Methods: This retrospective study was conducted on 540 patients underwent emergency appendectomy for the treatment of clinically suspected appendicitis at the department of p...
متن کاملA Phase II Study of BEZ235 in Patients with Everolimus-resistant, Advanced Pancreatic Neuroendocrine Tumours.
BACKGROUND This was a two-stage, phase II trial of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor BEZ235 in patients with everolimus-resistant pancreatic neuroendocrine tumours (pNETs) (NCT01658436). PATIENTS AND METHODS In stage 1, 11 patients received 400 mg BEZ235 orally twice daily (bid). Due to tolerability concerns, a further 20 patients received BEZ235 3...
متن کاملPhysiologically Based Pharmacokinetic (PBPK) model for biodistribution of radiolabeled peptides in patients with neuroendocrine tumours
Objective(s): The objectives of this work was to assess the benefits of the application of Physiologically Based Pharmacokinetic (PBPK) models in patients with different neuroendocrine tumours (NET) who were treatedwith Lu-177 DOTATATE. The model utilises clinical data on biodistribution of radiolabeled peptides (RLPs) obtained by whole body scintigraphy (WBS) of the patients.Methods: The blood...
متن کاملEverolimus in a Patient with Metastatic Neuroendocrine Tumor of the Rectum
At that time, five years after initial diagnosis, the patient first presented at our endocrine department for further treatment. 68Ga-DOTANOC-PET/CT revealed progressive, systemic disease with hepatic, lymphatic, and pulmonal metastases, without relevant tracer uptake. The patient was not willing to undergo systemic chemotherapy. We therefore discussed an off-label use of everolimus 10mg daily ...
متن کاملGuidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours.
Correspondence to: Dr J Ramage, North Hampshire Hospital, Aldermaston Road, Basingstoke, Hants, UK; johnramage1@ compuserve.com . . . . . . . . . . . . . . . . . . . . . . . 1.0 SUMMARY OF RECOMMENDATIONS 1.1 Genetics N Clinical examination to exclude complex cancer syndromes (for example, multiple endocrine neoplasia 1 (MEN1)) should be performed in all cases of neuroendocrine tumours (NETs), ...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Gastroenterology
سال: 2016
ISSN: 1756-2848,1756-2848
DOI: 10.1177/1756283x16674660